Recorded in Hawaii, Episode 8 of On the Mones moves from a beach observation about bodies and confidence to a practical deep dive into clonidine, one of the most underrated medications for perimenopause hot flushes, anxiety, ADHD and sleep.
In this episode Kate Thomas, an AHPRA-registered pharmacist with 25 years of clinical experience, covers:
Episode 8 opens on a Hawaiian beach with Kate watching her adult children in the surf, reflecting on how our relationship with our bodies shifts through perimenopause and midlife. The instinctive physical confidence of youth gives way to something more watchful, more cautious and more aware. Kate explores this shift with honesty and warmth, connecting the physical experience of perimenopause with the broader emotional and psychological changes of midlife, including how we see ourselves reflected in our daughters and the traits we find hardest to sit with.
Clonidine is one of the most underrated and underused medications in perimenopause care. Originally developed for blood pressure, it works by calming the body's stress response at the level of the nervous system, making it useful across a surprisingly wide range of conditions. In Episode 8, Kate breaks down clonidine clearly and practically, covering its use for perimenopause hot flushes, ADHD, anxiety, sleep disturbance and withdrawal syndromes. For women who cannot or choose not to use HRT, clonidine is an evidence-based option worth discussing with a GP, and a telehealth pharmacist consultation can help you understand whether it might be appropriate for your situation.
Beyond hot flushes, clonidine has a growing evidence base for ADHD and anxiety, two conditions that frequently emerge or worsen during perimenopause as estrogen declines. Kate explains the mechanism behind this clearly, helping women understand why a medication originally developed for blood pressure can have such a broad range of applications and why it needs to be used with respect and proper medical oversight.
Main character energy is the wellness world's latest reframe of calm, regulation and health as personal achievements, the idea that the most self-aware, regulated and intentional person in the room has somehow earned their state of being. Kate unpacks why this is not only scientifically inaccurate but genuinely harmful, explaining how calm, health and emotional regulation are shaped by biology, environment, privilege and access rather than effort or enlightenment. For women already carrying the weight of midlife, perimenopause and everything else, being told that peace is a practice they are simply not doing hard enough is the last thing they need.
If this episode has raised questions about clonidine, hot flushes, ADHD, anxiety or your perimenopause treatment options, a telehealth pharmacist consultation with Kate is a great next step. In a dedicated one-on-one session you can go through your symptoms, your current medications and your treatment options in plain language, without rushing.
Kate Thomas offers a range of in-depth telehealth medication consultation and medication review services to help you understand your body and your medications.
You can view the transcript for this episode below
On the Mones is hosted by Kate Thomas, an AHPRA-registered pharmacist with 25 years of clinical experience. Each episode breaks down hormones, perimenopause, menopause and medical misinformation with evidence-based clarity and zero judgment. Listened to in over 30 countries.
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